Methyl Isobutyl Ketone

Methyl Isobutyl Ketone

SCHEMBL9056069

CC(=O)CC(C)C.CCCC

nearest known ligand 0.82

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Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.82
TDP1 Q9NUW8 2/20 0.82
CA2 P00918 1/20 0.43
FFAR1 O14842 1/20 0.35
CYP2C19 P33261 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
POLB P06746 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TRPA1 O75762 1/20 0.33
MMP1 P03956 1/20 0.33
MMP2 P08253 1/20 0.33
MMP3 P08254 1/20 0.33
MMP9 P14780 1/20 0.33
MMP13 P45452 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methyl Isobutyl Ketone SCHEMBL1580340 0.91
Methyl Isobutyl Ketone SCHEMBL15458 0.91
Methyl Isobutyl Ketone SCHEMBL1128055 0.91 ALDH1A1 (1.00) ALDH1A1TDP1CA2FFAR1CYP2C19
Methyl Isobutyl Ketone SCHEMBL5000849 0.89 ALDH1A1 (0.74) ALDH1A1TDP1FFAR1
Methyl Isobutyl Ketone SCHEMBL108045 0.89 ALDH1A1 (0.74) ALDH1A1TDP1CA2FFAR1CYP2C19
Methyl Isobutyl Ketone SCHEMBL2340589 0.89 ALDH1A1 (0.74) ALDH1A1TDP1FFAR1
Methyl Isobutyl Ketone SCHEMBL104272 0.88 ALDH1A1 (0.82) ALDH1A1TDP1CA2CYP2C19SMN1; SMN2
Methyl Isobutyl Ketone SCHEMBL306141 0.88 ALDH1A1 (0.82) ALDH1A1TDP1CA2CYP2C19SMN1; SMN2
Methyl Isobutyl Ketone SCHEMBL842835 0.88
Methyl Isobutyl Ketone SCHEMBL8421472 0.88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0694541-A1 Process for the preparation of alpha-tocopherol Eisai Co., Ltd. (JP) 1996-01-31 EP disclosed