Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.70 |
| ▸ | TSHR | P16473 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15987720 | 0.93 | ALDH1A1 (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL28106548 | 0.93 | ALDH1A1 (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL6057066 | 0.93 | ALDH1A1 (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL15987525 | 0.93 | ALDH1A1 (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL5709964 | 0.93 | ALDH1A1 (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL15987671 | 0.93 | ALDH1A1 (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL28487576 | 0.93 | ALDH1A1 (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| Guanidine SCHEMBL27824211 | 0.91 | ALDH1A1 (0.84) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL8661935 | 0.91 | TSHR (0.81) | ALDH1A1TSHRLMNACYP3A4MAPK1 | |
| Guanidine SCHEMBL27443151 | 0.90 | ALDH1A1 (0.82) | ALDH1A1TSHRLMNACYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996015107-A1 | DITHIOCARBAMATE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-05-23 | — | — | WO | disclosed |