Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 3/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.41 |
| ▸ | EP300 | Q09472 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9492706 | 0.91 | POLB (0.56) | POLBGSK3BTP53LMNASMN1; SMN2 | |
| SCHEMBL9034916 | 0.88 | POLB (0.60) | POLBGSK3BTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9037176 | 0.87 | GSK3B (0.56) | POLBGSK3BTP53LMNASMN1; SMN2 | |
| SCHEMBL9494225 | 0.85 | POLB (0.44) | POLBGSK3BTP53LMNASMN1; SMN2 | |
| SCHEMBL9492717 | 0.81 | APAF1 (0.42) | POLBTP53SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9037918 | 0.79 | POLB (0.71) | POLBGSK3BGLAHSD17B10 | |
| SCHEMBL9037675 | 0.79 | POLB (0.60) | POLBGSK3BSMN1; SMN2MAPT | |
| SCHEMBL9037207 | 0.77 | POLB (0.61) | POLBGSK3BTP53SMN1; SMN2HDAC3 | |
| SCHEMBL9036209 | 0.77 | POLB (0.57) | POLBGSK3BSMN1; SMN2HDAC3HDAC6 | |
| SCHEMBL9035171 | 0.76 | POLB (0.60) | POLBGSK3BTP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0492667-B1 | 1,4-Benzothiazine-2-acetic acid derivatives, processes for production thereof and their use | GREEN CROSS CORP (JP) | 1996-04-17 | — | — | EP | disclosed |
| US-5252571-A | 1,4-benzothiazine-2-acetic acid derivatives | SAPPORO BREWERIES LIMITED (JP) | 1993-10-12 | — | — | US | disclosed |
| EP-0492667-A1 | 1,4-Benzothiazine-2-acetic acid derivatives, processes for production thereof and their use | THE GREEN CROSS CORPORATION (JP) | 1992-07-01 | — | — | EP | disclosed |