SCHEMBL9057318

SCHEMBL9057318

O=C(CC(=O)OC1CCc2c(n(Cc3ccccc3)c3ccccc23)C1)OC1CCc2c(n(Cc3ccccc3)c3ccccc23)C1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 10/20 0.48
HDAC1 Q13547 8/20 0.48
HDAC10 Q969S8 5/20 0.48
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
HDAC8 Q9BY41 3/20 0.45
CHRM2 P08172 1/20 0.45
HTR1A P08908 1/20 0.45
ADRA2A P08913 1/20 0.45
CHRM1 P11229 1/20 0.45
DRD1 P21728 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A4 P31645 1/20 0.45
ADRA1A P35348 1/20 0.45
OPRM1 P35372 1/20 0.45
DRD3 P35462 1/20 0.45
SLC6A3 Q01959 1/20 0.45
KCNH2 Q12809 1/20 0.45
HDAC3 O15379 2/20 0.44
HDAC2 Q92769 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9057029 0.96 HDAC6 (0.47) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL27489205 0.91 CA1 (0.46) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL9056969 0.89 CA1 (0.48) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL27475777 0.82 MEN1 (0.47) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL27471511 0.81 HDAC6 (0.41) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL27489204 0.81 HDAC6 (0.47) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL9055755 0.80 CHRM2 (0.50) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL7408065 0.79 HDAC6 (0.47) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL8387037 0.78 TBXA2R (0.52) HDAC6HDAC1HDAC10CA1CA2
SCHEMBL8387389 0.77 CA1 (0.53) HDAC6HDAC1HDAC10CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1166169-A Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors SANKYO CO (JP) 1997-11-26 CN disclosed
WO-1996003377-A1 HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS SANKYO COMPANY, LIMITED (JP) 1996-02-08 WO disclosed