Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | APP | P05067 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.50 |
| ▸ | SNCA | P37840 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179658 | 0.84 | HDAC1 (0.55) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL28808788 | 0.82 | HDAC8 (0.52) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL8388261 | 0.82 | HDAC1 (0.50) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL8685995 | 0.81 | HDAC8 (0.60) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL7079532 | 0.80 | HDAC1 (0.51) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL1608706 | 0.79 | HDAC8 (0.72) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL3595480 | 0.77 | LMNA (0.51) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL27475780 | 0.77 | HDAC8 (0.56) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL9057916 | 0.76 | APP (0.65) | BACE1HDAC8APPHDAC1HDAC2 | |
| SCHEMBL9057914 | 0.76 | APP (0.65) | BACE1HDAC8APPHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996003377-A1 | HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS | SANKYO COMPANY, LIMITED (JP) | 1996-02-08 | — | — | WO | disclosed |