SCHEMBL9060808

SCHEMBL9060808

CCCc1cnc(-c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)nc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 3/20 0.46
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HSD17B10 Q99714 1/20 0.43
KDM4E B2RXH2 1/20 0.43
RARB P10826 1/20 0.42
PRMT6 Q96LA8 1/20 0.41
SCN10A Q9Y5Y9 5/20 0.41
SCN5A Q14524 4/20 0.41
KCNH2 Q12809 2/20 0.41
SCN1A P35498 1/20 0.41
SCN9A Q15858 1/20 0.41
SCN2A Q99250 1/20 0.41
SCN8A Q9UQD0 1/20 0.41
MAPT P10636 2/20 0.41
THRB P10828 2/20 0.41
ADORA3 P0DMS8 1/20 0.40
RXRA P19793 1/20 0.39
GRIN1 Q05586 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5347935 0.98 CHRNA7 (0.47) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9060674 0.94 CHRNA7 (0.45) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9061575 0.92 RARB (0.49) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9061380 0.91 MRGPRX4 (0.43) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9061153 0.90 RARB (0.54) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9062389 0.90 RARB (0.50) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9062321 0.89 RXRA (0.47) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9060798 0.89 RARB (0.56) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9061796 0.89 RARB (0.56) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9060231 0.89 RARB (0.56) CHRNA7NPC1RAB9ASMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5536442-A ELECTROOPTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1996-07-16 US disclosed
US-5324449-A Substituted phenyl trifluoromethyl ethers MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-06-28 US disclosed
EP-0334911-B1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1993-02-10 EP disclosed
EP-0334911-A1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1989-10-04 EP disclosed
WO-1989002884-A1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1989-04-06 WO disclosed