SCHEMBL9062010

SCHEMBL9062010

CCCCCCc1ccc(C=Cc2ccc(OC(F)(F)F)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.49
THRB P10828 2/20 0.44
PPARG P37231 1/20 0.44
PPARA Q07869 1/20 0.44
CYP3A4 P08684 3/20 0.44
ESR1 P03372 2/20 0.44
ADRA2A P08913 2/20 0.44
ADORA3 P0DMS8 2/20 0.44
TACR2 P21452 2/20 0.44
SLC6A2 P23975 2/20 0.44
SLC6A4 P31645 2/20 0.44
SLC6A3 Q01959 2/20 0.44
ALDH1A1 P00352 2/20 0.44
LMNA P02545 2/20 0.44
KDM4E B2RXH2 1/20 0.44
SHBG P04278 1/20 0.44
TP53 P04637 1/20 0.44
HSPD1 P10809 1/20 0.44
ADRB3 P13945 1/20 0.44
HTR2C P28335 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9060456 1.00 FAAH (0.49) FAAHTHRBPPARGPPARACYP3A4
SCHEMBL9060462 1.00 FAAH (0.49) FAAHTHRBPPARGPPARACYP3A4
SCHEMBL9061691 1.00 FAAH (0.49) FAAHTHRBPPARGPPARACYP3A4
SCHEMBL9062000 1.00 FAAH (0.49) FAAHTHRBPPARGPPARACYP3A4
SCHEMBL9061689 1.00 FAAH (0.49) FAAHTHRBPPARGPPARACYP3A4
SCHEMBL9061347 0.98 FAAH (0.47) FAAHTHRBPPARGPPARACYP3A4
SCHEMBL9061353 0.98 FAAH (0.47) FAAHTHRBPPARGPPARACYP3A4
SCHEMBL9061030 0.94 PPARG (0.46) FAAHTHRBPPARGPPARASLC6A4
SCHEMBL9061019 0.94 PPARG (0.46) FAAHTHRBPPARGPPARASLC6A4
SCHEMBL20746961 0.91 FAAH (0.57) FAAHTHRBCYP3A4ESR1ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5536442-A ELECTROOPTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1996-07-16 US disclosed
US-5324449-A Substituted phenyl trifluoromethyl ethers MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-06-28 US disclosed
EP-0334911-B1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1993-02-10 EP disclosed
EP-0334911-A1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1989-10-04 EP disclosed