Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9063404 | 1.00 | PTGS2 (0.41) | PTGS2CYP11B2MMP3HRH3HDAC2 | |
| SCHEMBL9064292 | 0.86 | HDAC2 (0.43) | PTGS2MMP3HRH3HDAC2XDH | |
| SCHEMBL9065315 | 0.81 | BCL2L1 (0.50) | PTGS2HDAC2HDAC8 | |
| SCHEMBL9063938 | 0.81 | BCL2L1 (0.50) | PTGS2HDAC2HDAC8 | |
| SCHEMBL9063368 | 0.81 | PTGS2 (0.43) | PTGS2HDAC2HDAC8 | |
| SCHEMBL9064317 | 0.81 | BCL2L1 (0.50) | PTGS2HDAC2HDAC8 | |
| SCHEMBL9063633 | 0.81 | BCL2L1 (0.50) | PTGS2HDAC2HDAC8 | |
| SCHEMBL9063991 | 0.81 | PTGS2 (0.43) | PTGS2HDAC2HDAC8 | |
| SCHEMBL9063937 | 0.81 | BCL2L1 (0.50) | PTGS2HDAC2HDAC8 | |
| SCHEMBL9064312 | 0.81 | BCL2L1 (0.50) | PTGS2HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696272-A1 | CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING N(3-BIPHENYLYL-1(S)-METHYL-2-PROPENYL) ACETOHYDROXAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025431-A1 | CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING N(3-BIPHENYLYL-1(S)-METHYL-2-PROPENYL) ACETOHYDROXAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |