SCHEMBL9064338

SCHEMBL9064338

CCOC(=O)C(=CNC(N)=O)OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
CYP2D6 P10635 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ALOX15 P16050 1/20 0.40
NPSR1 Q6W5P4 2/20 0.37
GLO1 Q04760 1/20 0.37
DHODH Q02127 2/20 0.36
GAA P10253 3/20 0.35
MGAM O43451 1/20 0.35
SI P14410 1/20 0.35
MGAM2 Q2M2H8 1/20 0.35
EGLN1 Q9GZT9 1/20 0.35
MAPT P10636 3/20 0.34
CAD P27708 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26084789 0.81 CYP2D6 (0.56) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL3699121 0.79 GLO1 (0.42) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL8394432 0.76 GLO1 (0.58) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL14304405 0.76 NPSR1 (0.42) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL20210964 0.76 NPSR1 (0.42) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL7039853 0.76 NPSR1 (0.45) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL8399690 0.75 CYP2D6 (0.46) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL8694370 0.73 CYP2D6 (0.44) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL27588446 0.72 NPSR1 (0.42) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1
SCHEMBL12283185 0.71 NPSR1 (0.61) ALDH1A1CYP2D6SMN1; SMN2ALOX15NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0351193-B1 Surface coating compositions HARLOW CHEM CO LTD (GB) 1996-01-03 EP disclosed
US-5055504-A Pressure sensitive adhesive derived from dextrin, acrylate polymer, a surfactant and optionally a tackifier HARLOW CHEMICAL COMPANY LIMITED (GB) 1991-10-08 US disclosed
EP-0351193-A2 Surface coating compositions HARLOW CHEMICAL COMPANY LIMITED (GB) 1990-01-17 EP disclosed