Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PAM | P19021 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070847 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTPRNPNPSR1 | |
| SCHEMBL8905165 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTPRNPNPSR1 | |
| SCHEMBL15564842 | 0.83 | PPARA (0.55) | ACE | |
| SCHEMBL15564841 | 0.83 | PPARA (0.55) | ACE | |
| SCHEMBL13554636 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTTSHRCYP1A2 | |
| SCHEMBL13555268 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTTSHRCYP1A2 | |
| SCHEMBL9066405 | 0.80 | PRNP (0.42) | ALDH1A1MAPTPRNPNPSR1RXFP1 | |
| SCHEMBL15586930 | 0.79 | GLA (0.38) | ALDH1A1KDM4EMAPTTSHRCYP1A2 | |
| SCHEMBL12569086 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTTSHRCYP1A2 | |
| SCHEMBL12569143 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTTSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516936-A | TREATMENT OF NEUROLOGICAL DISORDERS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5495044-A | Inhibitors of kynureninase | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1996-02-27 | — | — | US | disclosed |
| WO-1995011878-A1 | INHIBITORS OF KYNURENINASE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1995-05-04 | — | — | WO | disclosed |
| EP-0581907-A4 | — | — | 1994-04-06 | — | — | EP | disclosed |
| EP-0581907-A1 | INHIBITORS OF KYNURENINASE | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1994-02-09 | — | — | EP | disclosed |
| WO-1992018003-A1 | INHIBITORS OF KYNURENINASE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1992-10-29 | — | — | WO | disclosed |