Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8676474 | 0.83 | LTB4R2 (0.41) | LTB4R2XDHSLC22A12KDM1ABRS3 | |
| SCHEMBL8676465 | 0.83 | LTB4R2 (0.50) | LTB4R2XDHSLC22A12BRS3 | |
| SCHEMBL7512343 | 0.77 | LTB4R2 (0.53) | LTB4R2XDHSLC22A12KDM1ABRS3 | |
| SCHEMBL8678080 | 0.76 | MPL (0.45) | LTB4R2KDM1ABRS3TSHRHSD17B10 | |
| SCHEMBL11753978 | 0.75 | LTB4R2 (0.53) | LTB4R2BRS3TSHRHSD17B10 | |
| SCHEMBL8678446 | 0.75 | TSHR (0.46) | LTB4R2TSHRHSD17B10 | |
| SCHEMBL8678895 | 0.75 | GRIA2 (0.41) | LTB4R2XDHSLC22A12BRS3GRIA2 | |
| SCHEMBL27746683 | 0.74 | PTPN11 (0.46) | MCL1GRM2 | |
| SCHEMBL9514700 | 0.74 | LTB4R2 (0.53) | LTB4R2BRS3TSHRHSD17B10 | |
| SCHEMBL9514122 | 0.73 | LTB4R2 (0.52) | LTB4R2BRS3MCL1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |