Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL4303048 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Lithium Ion SCHEMBL8614880 | 1.00 | — | — | |
| Lithium Ion SCHEMBL29728814 | 0.96 | — | — | |
| SCHEMBL30678822 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| SCHEMBL30369243 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| SCHEMBL30122785 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| SCHEMBL29669897 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| SCHEMBL8879449 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| SCHEMBL30370471 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Zinc Ion SCHEMBL868059 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236920-B2 | Polyarylene and process for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-07 | — | — | US | disclosed |
| EP-1995265-B1 | POLYARYLENE AND PROCESS FOR PRODUCING THE SAME | SUMITOMO CHEMICAL CO (JP) | 2012-08-01 | — | — | EP | disclosed |
| US-8207205-B2 | Compounds, compositions and methods comprising oxadiazole derivatives | INSTITUTE FOR ONEWORLD HEALTH (US) | 2012-06-26 | — | — | US | disclosed |
| US-20110160388-A1 | PROCESS FOR PRODUCTION OF MODIFIED CONJUGATED DIENE COPOLYMER, MODIFIED CONJUGATED DIENE COPOLYMER PRODUCED BY THE PROCESS, RUBBER COMPOSITION, AND TIRE | BRIDGESTONE CORPORATION (JP) | 2011-06-30 | — | — | US | disclosed |
| EP-2277940-A1 | PROCESS FOR PRODUCTION OF MODIFIED CONJUGATED DIENE COPOLYMER, MODIFIED CONJUGATED DIENE COPOLYMER PRODUCED BY THE PROCESS, RUBBER COMPOSITION, AND TIRE | Bridgestone Corporation (JP) | 2011-01-26 | — | — | EP | disclosed |
| US-20100016500-A1 | PROCESS FOR PRODUCING MODIFIED POLYMER, MODIFIED POLYMER OBTAINED BY THE PROCESS, AND RUBBER COMPOSITION CONTAINING THE SAME | JSR CORPORATION (JP) | 2010-01-21 | — | — | US | disclosed |
| US-20090326188-A1 | Method for producing polyarylene | SUMITOMO CHEMICAL COMPANY, LIMITED | 2009-12-31 | — | — | US | disclosed |
| US-20090264441-A1 | Compounds, Compositions and Methods Comprising Oxadiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-10-22 | — | — | US | disclosed |
| EP-2085419-A1 | PROCESS FOR PRODUCING MODIFIED POLYMER, MODIFIED POLYMER OBTAINED BY THE PROCESS, AND RUBBER COMPOSITION CONTAINING THE SAME | JSR Corporation (JP) | 2009-08-05 | — | — | EP | disclosed |
| EP-2065420-A1 | METHOD FOR PRODUCING POLYARYLENE | Sumitomo Chemical Company, Limited (JP) | 2009-06-03 | — | — | EP | disclosed |
| US-20090036632-A1 | Polyarylene and Process for Producing the Same | SUMITOMO CHEMICAL COMPANY, LIMITED | 2009-02-05 | — | — | US | disclosed |
| EP-1995265-A1 | POLYARYLENE AND PROCESS FOR PRODUCING THE SAME | Sumitomo Chemical Company, Limited (JP) | 2008-11-26 | — | — | EP | disclosed |
| US-20080287646-A1 | Polyarylene and Method for Producing the Same | SUMITOMO CHEMICAL COMPANY, LIMITED | 2008-11-20 | — | — | US | disclosed |
| EP-1935916-A1 | POLYARYLENE AND PROCESS FOR PRODUCING THE SAME | Sumitomo Chemical Company, Limited (JP) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036632-A1 | Polyarylene and Process for Producing the Same | CYP1A1, CYP1B1, C1R | TSHR 69/4885THRB 680/4885DNM1 3167/4885 |
| US-20090264441-A1 | Compounds, Compositions and Methods Comprising Oxadiazole Derivatives | CFTR, PKD1, PKD2 | TSHR 2636/4885THRB 2442/4885DNM1 418/4885 |
| US-20080287646-A1 | Polyarylene and Method for Producing the Same | CYP1A1, C1R, CBR1 | TSHR 307/4885THRB 1617/4885DNM1 2731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.