Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1022316 | 0.79 | RECQL (0.56) | RECQLUSP2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4327248 | 0.78 | USP2 (0.44) | RECQLUSP2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL13012231 | 0.78 | SSTR4 (0.42) | RECQLSMN1; SMN2HPGDKDM4ESSTR4 | |
| SCHEMBL22233403 | 0.77 | RECQL (0.48) | RECQLUSP2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL30860003 | 0.77 | CHRNB2 (0.53) | RECQLHPGDKDM4ESSTR4 | |
| SCHEMBL31464974 | 0.77 | CHRNB2 (0.53) | RECQLHPGDKDM4ESSTR4 | |
| SCHEMBL25262250 | 0.76 | SSTR4 (0.48) | SSTR4 | |
| Hydrochloric Acid SCHEMBL15322193 | 0.76 | SSTR4 (0.41) | RECQLSMN1; SMN2HPGDKDM4ESSTR4 | |
| Hydrochloric Acid SCHEMBL15322195 | 0.76 | SSTR4 (0.41) | RECQLSMN1; SMN2HPGDKDM4ESSTR4 | |
| SCHEMBL15408885 | 0.76 | SSTR4 (0.38) | SMN1; SMN2SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690713-A1 | SUBSTITUTED ALICYCLIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021254-A1 | SUBSTITUTED ALICYCLIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1994-09-29 | — | — | WO | disclosed |