⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628810 | 1.00 | — | — | |
| SCHEMBL628809 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL14813509 | 0.98 | CA1 (0.45) | — | |
| Hydrochloric Acid SCHEMBL1068300 | 0.98 | CA1 (0.45) | — | |
| Hydrochloric Acid SCHEMBL1068296 | 0.98 | CA1 (0.45) | — | |
| SCHEMBL10402326 | 0.90 | CA1 (0.40) | — | |
| SCHEMBL11776470 | 0.87 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL3649449 | 0.86 | CA1 (0.59) | — | |
| SCHEMBL628944 | 0.86 | CA1 (0.59) | — | |
| SCHEMBL186090 | 0.86 | CA1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760862-B1 | 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI SA (FR) | 2015-10-21 | — | — | EP | disclosed |
| EP-2760862-A1 | 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045413-A1 | 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2013-04-04 | — | — | WO | disclosed |
| US-20130085128-A1 | 6-(4-Hydroxy-phenyl)-3-alkyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors | SANOFI (FR) | 2013-04-04 | — | — | US | disclosed |
| CN-101448830-A | Dihydropteridine compounds as anti proliferative agents | ASTRAZENECA AB (SE) | 2009-06-03 | — | — | CN | disclosed |
| US-5536750-A | ANTITUMOR | MERCK & CO., INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0668856-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE. | MERCK & CO INC (US) | 1995-11-22 | — | — | EP | disclosed |
| EP-0668856-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-30 | — | — | EP | disclosed |
| US-5326773-A | Prodrug enzyme inhibitors | MERCK & CO., INC. (US) | 1994-07-05 | — | — | US | disclosed |
| WO-1994010137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |
| US-4929736-A | INHIBITORS OF ELASTASE, AZOLIDES | BOARD OF TRUSTEES OF THE WICHITA STATE UNIVERSITY (US) | 1990-05-29 | — | — | US | disclosed |
| EP-0209855-A2 | Amino acid derivatives useful for deactivating enzymes | Board of Trustees of Wichita State University (US) | 1987-01-28 | — | — | EP | disclosed |