Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.50 |
| ▸ | REN | P00797 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PEPD | P12955 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068494 | 1.00 | ACE (0.50) | ACERENNPSR1KDM4EF2 | |
| SCHEMBL9068492 | 1.00 | ACE (0.50) | ACERENNPSR1KDM4EF2 | |
| SCHEMBL7378528 | 0.88 | ACE (0.62) | ACERENKDM4EF2LMNA | |
| SCHEMBL10954711 | 0.88 | ACE (0.62) | ACERENKDM4EF2LMNA | |
| SCHEMBL10508293 | 0.88 | ACE (0.62) | ACERENKDM4EF2LMNA | |
| SCHEMBL5567090 | 0.85 | ACE (0.50) | ACERENKDM4EF2LMNA | |
| SCHEMBL11497741 | 0.84 | ACE (0.61) | ACEACE2KMT2A | |
| SCHEMBL11286625 | 0.84 | ACE (0.58) | ACEACE2KMT2A | |
| SCHEMBL24378504 | 0.82 | SLC6A1 (0.52) | ACERENNPSR1KDM4EF2 | |
| SCHEMBL5566810 | 0.81 | ACE (0.44) | ACERENKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304570-A | Ibopamine or salt and enzyme inhibitor (S,S),-N-(3-(4-methoxybenzoylthio)-2-methyl-propionyl)-proline) | ZAMBON GROUP S.P.A. (IT) | 1994-04-19 | — | — | US | claimed |
| EP-0351017-B1 | Pharmaceutical composition useful for the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1994-01-19 | — | — | EP | claimed |
| EP-0351017-A2 | Pharmaceutical composition useful for the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1990-01-17 | — | — | EP | claimed |
| JP-2096564-A | — | — | None | — | — | JP | disclosed |
| US-5571834-A | HYPOTENSIVE AGENTS | ZAMBON GROUP S.P.A. (IT) | 1996-11-05 | — | — | US | disclosed |
| US-5304570-A | Ibopamine or salt and enzyme inhibitor (S,S),-N-(3-(4-methoxybenzoylthio)-2-methyl-propionyl)-proline) | ZAMBON GROUP S.P.A. (IT) | 1994-04-19 | — | — | US | disclosed |
| EP-0351017-B1 | Pharmaceutical composition useful for the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1994-01-19 | — | — | EP | disclosed |
| JP-H0296564-A | DRUG COMPOSITION AND (SS)-N-(3-(4-METHOXYBENZOYLTHIO)-2-METHYL-PROPYL)-PROLINE | SIMES SPA | 1990-04-09 | — | — | JP | disclosed |
| EP-0351017-A2 | Pharmaceutical composition useful for the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1990-01-17 | — | — | EP | disclosed |
| JP-H00296564-A | — | — | 0001-01-01 | — | — | JP | disclosed |