Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 5/20 | 0.57 |
| ▸ | MME | P08473 | 3/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | EED | O75530 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CPA1 | P15085 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9069215 | 1.00 | PSMB5 (0.57) | PSMB5MMEMMP9EEDACE | |
| SCHEMBL10944288 | 0.98 | MMP9 (0.57) | PSMB5MMEMMP9EEDACE | |
| SCHEMBL10736781 | 0.89 | PSMB5 (0.59) | PSMB5MMEEEDLMNATDP1 | |
| SCHEMBL10737452 | 0.89 | PSMB5 (0.59) | PSMB5MMEEEDLMNATDP1 | |
| SCHEMBL9068940 | 0.89 | PSMB5 (0.59) | PSMB5MMEEEDLMNATDP1 | |
| SCHEMBL9068941 | 0.89 | PSMB5 (0.59) | PSMB5MMEEEDLMNATDP1 | |
| SCHEMBL9069586 | 0.88 | MME (0.55) | PSMB5MMEMMP9EEDACE | |
| SCHEMBL9069587 | 0.88 | MME (0.55) | PSMB5MMEMMP9EEDACE | |
| SCHEMBL10949155 | 0.87 | PSMB5 (0.56) | PSMB5MMEEEDLMNATDP1 | |
| SCHEMBL10949165 | 0.87 | PSMB5 (0.56) | PSMB5MMEEEDLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560506-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-12-24 | — | — | US | claimed |
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| US-4560506-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-12-24 | — | — | US | disclosed |