Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.59 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9073082 | 0.97 | KMT5B (0.62) | KMT5BKMT5CS1PR1S1PR3IDO1 | |
| SCHEMBL30307410 | 0.77 | KMT5B (0.62) | KMT5BKMT5CS1PR1S1PR3IDO1 | |
| SCHEMBL17241563 | 0.76 | KMT5B (0.59) | KMT5BKMT5CCYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9070436 | 0.75 | KDM4E (0.55) | KMT5BKMT5CS1PR1IDO1CYP2D6 | |
| SCHEMBL529480 | 0.74 | MELK (0.59) | KMT5BKMT5CDYRK1ADYRK1BMAPKAPK2 | |
| SCHEMBL529479 | 0.74 | MELK (0.59) | KMT5BKMT5CDYRK1ADYRK1BMAPKAPK2 | |
| SCHEMBL2621803 | 0.73 | SLC22A12 (0.55) | KMT5BKMT5CCYP2D6CYP2C19KDM4E | |
| SCHEMBL12871473 | 0.72 | KMT5B (0.97) | KMT5BKMT5CCYP2D6CYP2C19KDM4E | |
| SCHEMBL9069386 | 0.70 | SYK (0.48) | RIPK2KDRMAPK14RETMAPKAPK2 | |
| SCHEMBL6071399 | 0.70 | KMT5B (0.52) | KMT5BKMT5CCYP2D6NSD2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506235-A | Quinoline derivatives as immunostimulants | PFIZER INC. (US) | 1996-04-09 | — | — | US | disclosed |