Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.52 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.52 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 4/20 | 0.43 |
| ▸ | CDK8 | P49336 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5948265 | 0.85 | LRRK2 (0.47) | KMT5BKMT5CLMNACYP1A2CYP2D6 | |
| SCHEMBL27728186 | 0.76 | SRC (0.61) | IP6K1DYRK1ADYRK1B | |
| SCHEMBL30307410 | 0.74 | KMT5B (0.62) | KMT5BKMT5CLMNACYP2D6SMN1; SMN2 | |
| SCHEMBL27896914 | 0.72 | HTT (0.53) | LMNACYP1A2CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL9073082 | 0.72 | KMT5B (0.62) | KMT5BKMT5CIP6K1CYP2D6SMN1; SMN2 | |
| SCHEMBL17241563 | 0.71 | KMT5B (0.59) | KMT5BKMT5CCYP2D6CCNCCDK8 | |
| SCHEMBL6071484 | 0.70 | HRH3 (0.57) | LMNAHTTACHENSD2ROCK2 | |
| Bromide SCHEMBL9070504 | 0.70 | KMT5B (0.59) | KMT5BKMT5CIP6K1CYP2D6SMN1; SMN2 | |
| SCHEMBL6598616 | 0.70 | EGFR (0.63) | PKMLMNAHTTSMN1; SMN2CCNC | |
| SCHEMBL29337531 | 0.70 | HTR1A (0.68) | PKMLMNAHTTSMN1; SMN2CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | KMT5B 1577/4885KMT5C 2048/4885IP6K1 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.