Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.87 |
| ▸ | NOS2 | P35228 | 5/20 | 0.56 |
| ▸ | NOS1 | P29475 | 4/20 | 0.56 |
| ▸ | NOS3 | P29474 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | ARG2 | P78540 | 4/20 | 0.53 |
| ▸ | ARG1 | P05089 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.52 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL29126333 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL30642401 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL30642405 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL29397119 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL28422142 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL124167 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL7131633 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL2400402 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL2400405 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL30647269 | 1.00 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543316-A | INCLUDING A SUGAR, A SERUM ALBUMIN, A CALCIUM SALT, A PHOSPHATE SALT, A SOURCE OF IRON, AMINO ACIDS, VITAMINS, GROUP I SALT AND A GROUP II SALT | DIACRIN, INC. (US) | 1996-08-06 | — | — | US | claimed |
| US-5543316-A | INCLUDING A SUGAR, A SERUM ALBUMIN, A CALCIUM SALT, A PHOSPHATE SALT, A SOURCE OF IRON, AMINO ACIDS, VITAMINS, GROUP I SALT AND A GROUP II SALT | DIACRIN, INC. (US) | 1996-08-06 | — | — | US | disclosed |