Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 9/20 | 0.71 |
| ▸ | FFAR2 | O15552 | 5/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9071103 | 0.88 | GCK (0.73) | GCKFFAR2KCNH2LMNAXBP1 | |
| SCHEMBL2659048 | 0.86 | GCK (0.77) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL9071131 | 0.86 | GCK (0.71) | GCKFFAR2KCNH2LMNAXBP1 | |
| SCHEMBL9071127 | 0.86 | GCK (0.71) | GCKFFAR2KCNH2LMNAXBP1 | |
| SCHEMBL2644739 | 0.85 | GCK (0.76) | GCKFFAR2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL27481667 | 0.85 | GCK (0.69) | GCKFFAR2KCNH2LMNAXBP1 | |
| SCHEMBL27480871 | 0.85 | GCK (0.69) | GCKFFAR2KCNH2LMNAXBP1 | |
| SCHEMBL2645293 | 0.84 | GCK (0.74) | GCKFFAR2KCNH2LMNACYP1A2 | |
| SCHEMBL2646757 | 0.84 | FFAR2 (0.91) | GCKFFAR2KCNH2LMNACYP1A2 | |
| SCHEMBL2645871 | 0.84 | GCK (0.74) | GCKFFAR2KCNH2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001083465-A2 | ALKYNYL PHENYL HETEROAROMATIC GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |