Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 13/20 | 0.72 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.72 |
| ▸ | EGFR | P00533 | 8/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | INSR | P06213 | 1/20 | 0.69 |
| ▸ | FBP1 | P09467 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | FLT4 | P35916 | 1/20 | 0.69 |
| ▸ | CLK1 | P49759 | 1/20 | 0.69 |
| ▸ | TEK | Q02763 | 1/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL907176 | 0.99 | KDR (0.71) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL14863005 | 0.92 | EGFR (0.84) | KDREPHB4ERBB2EGFRAURKA | |
| SCHEMBL2100447 | 0.90 | KDR (0.80) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL5911655 | 0.87 | EGFR (0.86) | KDREPHB4ERBB2EGFRAURKA | |
| SCHEMBL16295327 | 0.86 | EGFR (0.78) | KDREPHB4ERBB2EGFRAURKA | |
| Hydrochloric Acid SCHEMBL5911498 | 0.86 | EGFR (0.84) | KDREPHB4ERBB2EGFRAURKA | |
| SCHEMBL15217652 | 0.86 | FBP1 (0.78) | KDREPHB4ERBB2EGFRAURKA | |
| SCHEMBL907406 | 0.85 | KDR (0.68) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL30520472 | 0.84 | EGFR (0.87) | KDREPHB4ERBB2EGFRAURKA | |
| SCHEMBL13524614 | 0.84 | EGFR (0.87) | KDREPHB4ERBB2EGFRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521747-B1 | RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE | SYMPHONY EVOLUTION INC (US) | 2018-09-05 | — | — | EP | disclosed |
| EP-2277867-B1 | Compounds, pharmaceutical compositions thereof and their use in treating cancer | SYMPHONY EVOLUTION INC (US) | 2012-12-05 | — | — | EP | disclosed |
| EP-2280003-A2 | Process for preparing receptor-type kinase modulators | Symphony Evolution, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| EP-2277867-A2 | Compounds, pharmaceutical compositions thereof and their use in treating cancer | Symphony Evolution, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| EP-1521747-A4 | RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2006-10-11 | — | — | EP | disclosed |
| EP-1521747-A2 | RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004006846-A2 | RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2004-01-22 | — | — | WO | disclosed |