Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186396 | 1.00 | GCK (0.53) | GCKKCNH2RIPK1CCNB2CDK1 | |
| SCHEMBL708896 | 0.86 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL708895 | 0.86 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL2087103 | 0.82 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL4181761 | 0.81 | RIPK1 (0.52) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL1528463 | 0.79 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL1528466 | 0.79 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL425758 | 0.79 | GCK (0.63) | GCKKCNH2 | |
| SCHEMBL423259 | 0.79 | GCK (0.51) | GCKKCNH2 | |
| SCHEMBL9986939 | 0.79 | GCK (0.78) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007031739-A1 | HETEROBICYCLIC COMPOUNDS AS GLUCOKINASE ACTIVATORS | ASTRAZENECA AB (SE) | 2007-03-22 | — | — | WO | disclosed |