SCHEMBL9072017

SCHEMBL9072017

COc1cc(OCCNCc2ccc(Cl)c(Cl)c2)ccc1/C=N/NC(=O)c1ccc(O)c(Cl)c1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCGR P47871 19/20 0.80
ADCYAP1R1 P41586 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2664471 0.93 GCGR (0.72) GCGRADCYAP1R1
SCHEMBL9072021 0.93 GCGR (0.84) GCGRADCYAP1R1
SCHEMBL2664468 0.89 GCGR (0.86) GCGRADCYAP1R1
SCHEMBL9072062 0.89 GCGR (1.00) GCGRADCYAP1R1
SCHEMBL9072028 0.87 GCGR (0.73) GCGRADCYAP1R1
SCHEMBL2664467 0.86 GCGR (0.72) GCGRADCYAP1R1
SCHEMBL2663962 0.85 ADCYAP1R1 (0.66) GCGRADCYAP1R1
SCHEMBL2664375 0.83 GCGR (1.00) GCGR
SCHEMBL2663961 0.82 GCGR (0.61) GCGRADCYAP1R1
SCHEMBL9072112 0.81 GCGR (0.82) GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999001423-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 1999-01-14 WO disclosed