Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.71 |
| ▸ | ALPI | P09923 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | XIAP | P98170 | 1/20 | 0.71 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL271922 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL28549527 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL271920 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1537214 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1537209 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL18222727 | 0.93 | SLC7A5 (0.89) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL5699039 | 0.93 | SLC7A5 (0.89) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL133206 | 0.93 | SLC7A5 (0.89) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL5699043 | 0.93 | SLC7A5 (0.89) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1003558 | 0.93 | SLC7A5 (0.89) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5520911-A | Variants of plasminogen activators and processes for their production | GENENTECH, INC. (US) | 1996-05-28 | — | — | US | disclosed |
| US-5385732-A | For treatment of vascular disorders, longer circulating half-lives, slower clearance rates | GENENTECH, INC. (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0424405-B1 | VARIANTS OF PLASMINOGEN ACTIVATORS AND PROCESSES FOR THEIR PRODUCTION | GENENTECH INC (US) | 1994-09-14 | — | — | EP | disclosed |
| US-5346824-A | Treatment of vascular disease, anticoagulants, lysis of fibrin | GENENTECH, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5270198-A | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells | GENENTECH, INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0424405-A1 | VARIANTS OF PLASMINOGEN ACTIVATORS AND PROCESSES FOR THEIR PRODUCTION. | GENENTECH INC (US) | 1991-05-02 | — | — | EP | disclosed |
| WO-1989011531-A1 | VARIANTS OF PLASMINOGEN ACTIVATORS AND PROCESSES FOR THEIR PRODUCTION | GENENTECH, INC. (US) | 1989-11-30 | — | — | WO | disclosed |