Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 2/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Picolamine SCHEMBL11594024 | 0.90 | CHRNA7 (0.55) | CHRNA7CYP2A6NAPRTCYP1A2RECQL | |
| SCHEMBL9074694 | 0.82 | CHRNA7 (0.47) | CHRNA7CYP2A6NAPRTKDM4EHRH1 | |
| Picolamine SCHEMBL29394769 | 0.82 | — | — | |
| Picolamine SCHEMBL30046657 | 0.82 | — | — | |
| Picolamine SCHEMBL17850 | 0.82 | — | — | |
| Picolamine SCHEMBL2674094 | 0.80 | — | — | |
| Picolamine SCHEMBL7984435 | 0.80 | — | — | |
| Picolamine SCHEMBL2404845 | 0.80 | — | — | |
| Picolamine SCHEMBL5012162 | 0.80 | CHRNA7 (0.65) | CHRNA7CYP2A6NAPRTCYP1A2RECQL | |
| Picolamine SCHEMBL11870934 | 0.80 | CHRNA7 (0.65) | CHRNA7CYP2A6NAPRTCYP1A2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583122-A | TREATING DISEASES ASSOCIATED WITH ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | THE PROCTER & GAMBLE COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0586521-A1 | CALCIUM, TRACE MINERAL, VITAMIN D AND DRUG THERAPY COMBINATIONS | THE PROCTER & GAMBLE COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5283057-A | Risedronate in oral compositions | THE PROCTER & GAMBLE COMPANY (US) | 1994-02-01 | — | — | US | disclosed |
| WO-1992021355-A1 | CALCIUM, TRACE MINERAL, VITAMIN D AND DRUG THERAPY COMBINATIONS | THE PROCTER & GAMBLE COMPANY (US) | 1992-12-10 | — | — | WO | disclosed |
| EP-0186405-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING GEMINAL DIPHOSPHONATES | THE PROCTER & GAMBLE COMPANY (US) | 1991-03-06 | — | — | EP | disclosed |
| EP-0186405-A2 | Pharmaceutical compositions containing geminal diphosphonates | THE PROCTER & GAMBLE COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| US-4100167-A | Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system | NALCO CHEMICAL COMPANY (US) | 1978-07-11 | — | — | US | disclosed |