SCHEMBL9074674

SCHEMBL9074674

COC1(c2cnc(S(=O)(=O)c3ccc(/C(C)=N/O)c(CC#N)c3)s2)CCOCC1

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.43
TYK2 P29597 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9076713 0.83
SCHEMBL9049132 0.81 ALOX5 (0.37) ALOX5
SCHEMBL9075180 0.80 ALOX5 (0.43) ALOX5
SCHEMBL9045431 0.80 ALOX5 (0.40) ALOX5
SCHEMBL9075800 0.80 ALOX5 (0.35) ALOX5
SCHEMBL9074240 0.74 ALOX5 (0.32) ALOX5
SCHEMBL9075763 0.74 ALOX5 (0.34) ALOX5
SCHEMBL9050402 0.70
SCHEMBL9075114 0.70 ALOX5 (0.37) ALOX5
SCHEMBL9126981 0.70 ALOX5 (0.53) ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5482966-A LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS ZENECA LIMITED (GB) 1996-01-09 US disclosed
US-5332757-A Enzyme inhibitors ZENECA LIMITED (GB) 1994-07-26 US disclosed