Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PRCP | P42785 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.51 |
| ▸ | PREP | P48147 | 4/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9075679 | 1.00 | HTT (0.54) | HTTPRCPMEN1KMT2ADPP4 | |
| SCHEMBL3342656 | 0.88 | PREP (0.57) | MEN1KMT2ADPP4DPP8DPP9 | |
| SCHEMBL25186706 | 0.88 | PREP (0.57) | MEN1KMT2ADPP4DPP8DPP9 | |
| SCHEMBL3336958 | 0.88 | PREP (0.57) | MEN1KMT2ADPP4DPP8DPP9 | |
| SCHEMBL28978206 | 0.85 | FKBP1A (0.54) | MEN1KMT2ADPP4DPP8DPP9 | |
| SCHEMBL25174182 | 0.85 | FKBP1A (0.54) | MEN1KMT2ADPP4DPP8DPP9 | |
| SCHEMBL20522842 | 0.85 | FKBP1A (0.54) | MEN1KMT2ADPP4DPP8DPP9 | |
| SCHEMBL9076809 | 0.84 | DPP4 (0.47) | HTTPRCPMEN1KMT2ADPP4 | |
| SCHEMBL9076807 | 0.84 | DPP4 (0.47) | HTTPRCPMEN1KMT2ADPP4 | |
| SCHEMBL25174200 | 0.84 | PREP (0.55) | HTTMEN1KMT2ADPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0623596-A1 | N-acylpyrrolidines or N-acylpiperidines having a guanidinyl- or amidinyl-substituted side chain as thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |