Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | BLM | P54132 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | THPO | P40225 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9076140 | 0.91 | KCNH2 (0.62) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL9076363 | 0.88 | KCNH2 (0.70) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL9076057 | 0.87 | KCNH2 (0.79) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL18590354 | 0.86 | KCNH2 (0.77) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL17023760 | 0.86 | KCNH2 (0.77) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL11869223 | 0.86 | KCNH2 (0.74) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL2615108 | 0.81 | KCNH2 (0.90) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL11860646 | 0.81 | KCNH2 (0.74) | KCNH2LMNAHRH1DRD3BLM | |
| SCHEMBL9500310 | 0.79 | HTR2A (0.64) | BLMHTTHTR2AGMNNCYP3A4 | |
| SCHEMBL13285122 | 0.78 | LMNA (0.91) | KCNH2LMNAHRH1DRD3BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563134-B1 | AGENTS FOR POTENTIATING THE EFFECTS OF ANTITUMOR AGENTS AND COMBATING MULTIPLE DRUG RESISTANCE | WELLCOME FOUND (GB) | 1996-06-19 | — | — | EP | disclosed |
| US-5416091-A | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | BURROUGHS WELLCOME CO. (US) | 1995-05-16 | — | — | US | disclosed |
| EP-0563134-A1 | AGENTS FOR POTENTIATING THE EFFECTS OF ANTITUMOR AGENTS AND COMBATING MULTIPLE DRUG RESISTANCE. | WELLCOME FOUND (GB) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011034-A1 | AGENTS FOR POTENTIATING THE EFFECTS OF ANTITUMOR AGENTS AND COMBATING MULTIPLE DRUG RESISTANCE | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-07-09 | — | — | WO | disclosed |