Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.30 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11904856 | 1.00 | OPRK1 (0.32) | OPRK1SIGMAR1SOAT1DAGLA | |
| SCHEMBL11928190 | 1.00 | OPRK1 (0.32) | OPRK1SIGMAR1SOAT1DAGLA | |
| SCHEMBL11928235 | 1.00 | OPRK1 (0.32) | OPRK1SIGMAR1SOAT1DAGLA | |
| SCHEMBL907628 | 1.00 | OPRK1 (0.32) | OPRK1SIGMAR1SOAT1DAGLA | |
| SCHEMBL11928189 | 1.00 | OPRK1 (0.32) | OPRK1SIGMAR1SOAT1DAGLA | |
| SCHEMBL13269859 | 0.91 | SLC6A4 (0.33) | — | |
| SCHEMBL13269858 | 0.91 | SLC6A4 (0.33) | — | |
| SCHEMBL1728506 | 0.91 | CETP (0.34) | — | |
| SCHEMBL1200502 | 0.91 | CETP (0.34) | — | |
| SCHEMBL1199605 | 0.91 | CETP (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276756-B9 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2012010862-A3 | IMPROVED COMBUSTIBLE COMPOSITION | RECKITT BENCKISER SOUTH AFRICA (PTY) LIMITED (ZA) | 2012-05-10 | — | — | WO | disclosed |
| EP-2276756-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | Merck Sharp & Dohme Corp. (US) | 2011-01-26 | — | — | EP | disclosed |