Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 4/20 | 0.43 |
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9076477 | 1.00 | ACE2 (0.44) | ACE2ACEDPP4DPP8DPP9 | |
| SCHEMBL9074561 | 0.97 | ACE2 (0.42) | ACE2ACEDPP4DPP8DPP9 | |
| SCHEMBL9074564 | 0.97 | ACE2 (0.42) | ACE2ACEDPP4DPP8DPP9 | |
| SCHEMBL9073915 | 0.91 | ACE (0.42) | ACE2ACEATML3MBTL1 | |
| SCHEMBL9073912 | 0.91 | ACE (0.42) | ACE2ACEATML3MBTL1 | |
| SCHEMBL9073824 | 0.90 | ACE2 (0.41) | ACE2ACEDPP4DPP8DPP9 | |
| SCHEMBL9073821 | 0.90 | ACE2 (0.41) | ACE2ACEDPP4DPP8DPP9 | |
| SCHEMBL9414142 | 0.88 | ACE (0.51) | ACEF2PRSS1 | |
| SCHEMBL9414140 | 0.88 | ACE (0.51) | ACEF2PRSS1 | |
| SCHEMBL9075695 | 0.87 | DPP4 (0.41) | ACE2ACEDPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0623596-A1 | N-acylpyrrolidines or N-acylpiperidines having a guanidinyl- or amidinyl-substituted side chain as thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |