Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.77 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.75 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28981386 | 0.88 | SIRT1 (0.73) | SIRT1SIRT2SIRT3HDAC1NR1H4 | |
| SCHEMBL28981406 | 0.88 | SIRT1 (0.73) | SIRT1SIRT2SIRT3HDAC1NR1H4 | |
| SCHEMBL28981419 | 0.88 | SIRT1 (0.73) | SIRT1SIRT2SIRT3HDAC1NR1H4 | |
| SCHEMBL907810 | 0.88 | SIRT1 (0.78) | SIRT1SIRT2SIRT3 | |
| SCHEMBL907340 | 0.87 | SIRT1 (0.78) | SIRT1SIRT2SIRT3 | |
| SCHEMBL907692 | 0.87 | SIRT1 (0.78) | SIRT1SIRT2SIRT3 | |
| Hydrochloric Acid SCHEMBL907138 | 0.86 | SIRT1 (1.00) | SIRT1SIRT2SIRT3 | |
| SCHEMBL907437 | 0.85 | SIRT1 (0.76) | SIRT1SIRT2SIRT3 | |
| SCHEMBL907439 | 0.81 | SIRT1 (0.55) | SIRT1SIRT2SIRT3HDAC1NR1H4 | |
| SCHEMBL8218803 | 0.78 | NR1H4 (0.63) | SIRT1SIRT2NR1H4EPHX2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501991-B2 | P53 activating compounds | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2013-08-06 | — | — | US | disclosed |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2011-01-27 | — | — | US | disclosed |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2011-01-27 | — | — | US | disclosed |
| EP-2099445-B1 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIV DUNDEE (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2008029096-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | TP53, TP53BP1, SIRT1 | SIRT1 3/4885SIRT2 6/4885SIRT3 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.