Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TTR | P02766 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 8/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12758924 | 0.82 | HSD17B10 (0.52) | HSD17B10TTRESR1CA12CA1 | |
| SCHEMBL13594635 | 0.78 | EGFR (0.40) | HSD17B10ESR1CA12CA1CA2 | |
| SCHEMBL14540599 | 0.77 | HSD17B10 (0.46) | HSD17B10TTRESR1CA12CA1 | |
| SCHEMBL14074204 | 0.76 | AHR (0.48) | TTRESR1CA12CA9ESR2 | |
| SCHEMBL9290659 | 0.76 | TP53 (0.48) | HSD17B10CYP3A4HPGDMEN1KMT2A | |
| SCHEMBL532655 | 0.76 | EGFR (0.54) | HSD17B10CA12CA1CA2CA7 | |
| SCHEMBL31218219 | 0.76 | TP53 (0.48) | HSD17B10CYP3A4HPGDMEN1KMT2A | |
| SCHEMBL28253003 | 0.74 | MAPK1 (0.39) | HSD17B10CYP3A4HPGDMEN1KMT2A | |
| SCHEMBL7878843 | 0.73 | CYP3A4 (0.52) | HSD17B10CA1CA2CYP3A4HPGD | |
| SCHEMBL10058199 | 0.73 | ESR1 (0.41) | HSD17B10ESR1ESR2HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8019095-B2 | — | — | 1996-02-28 | — | — | JP | claimed |
| EP-0302874-B1 | INDOLOQUINONE COMPOUNDS | SPECKAMP, Willem Nico (NL) | 1992-12-02 | — | — | EP | claimed |
| EP-0302874-A1 | INDOLOQUINONE COMPOUNDS. | SPECKAMP WILLEM NICO (NL) | 1989-02-15 | — | — | EP | claimed |
| WO-1987006227-A2 | INDOLOQUINONE COMPOUNDS | JOUHAR AKBAR JAN (GB) | 1987-10-22 | — | — | WO | claimed |
| EP-0302874-B1 | INDOLOQUINONE COMPOUNDS | SPECKAMP, Willem Nico (NL) | 1992-12-02 | — | — | EP | disclosed |
| US-5079257-A | Antitumor Agents | SPECTRUM PHARMACEUTICALS, INC. | 1992-01-07 | — | — | US | disclosed |