Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 6/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9077319 | 1.00 | HTT (0.32) | HTTBRAFMAPK3MAPK1ALOX5 | |
| SCHEMBL9046849 | 0.86 | ALOX5 (0.37) | ALOX5 | |
| SCHEMBL9076846 | 0.83 | HTT (0.33) | HTTBRAFMAPK3MAPK1ALOX5 | |
| SCHEMBL9076849 | 0.83 | HTT (0.33) | HTTBRAFMAPK3MAPK1ALOX5 | |
| SCHEMBL9077130 | 0.83 | HTT (0.33) | HTTBRAFMAPK3MAPK1ALOX5 | |
| SCHEMBL9077136 | 0.83 | HTT (0.33) | HTTBRAFMAPK3MAPK1ALOX5 | |
| SCHEMBL9077133 | 0.83 | HTT (0.33) | HTTBRAFMAPK3MAPK1ALOX5 | |
| SCHEMBL9076151 | 0.81 | ALOX5 (0.43) | HTTALOX5 | |
| SCHEMBL9076160 | 0.81 | ALOX5 (0.43) | HTTALOX5 | |
| SCHEMBL9076156 | 0.81 | ALOX5 (0.43) | HTTALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |