Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.59 |
| ▸ | PPARA | Q07869 | 5/20 | 0.59 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.55 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 6/20 | 0.50 |
| ▸ | CTSK | P43235 | 5/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9077727 | 1.00 | PPARG (0.59) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL14021750 | 0.91 | PPARG (0.55) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL4887436 | 0.91 | PPARG (0.55) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL4597517 | 0.91 | PPARG (0.55) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL14021649 | 0.89 | ITGB3 (0.55) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL4889863 | 0.89 | ITGB3 (0.55) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL4889870 | 0.89 | ITGB3 (0.55) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL23704405 | 0.85 | ACE (0.60) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL5227204 | 0.85 | ACE (0.60) | PPARGPPARAACEITGB3ITGA2B | |
| SCHEMBL9078660 | 0.84 | PPARA (0.51) | PPARGPPARAACECTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508437-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5296608-A | Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides | HOFFMAN-LA ROCHE INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5182263-A | Appetite suppressants | HOFFMANN-LA ROCHE INC. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0339549-A2 | Tyr-peptide analogs | F. HOFFMANN-LA ROCHE AG (CH) | 1989-11-02 | — | — | EP | disclosed |