Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.47 |
| ▸ | HPGD | P15428 | 8/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 4/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078737 | 0.96 | KDM4E (0.49) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9079778 | 0.91 | ALDH1A1 (0.44) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9080772 | 0.89 | KCNH2 (0.45) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9080381 | 0.87 | ALDH1A1 (0.45) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9078074 | 0.87 | KDM4E (0.52) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9079800 | 0.85 | KDM4E (0.66) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9079551 | 0.85 | ALDH1A1 (0.56) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9078290 | 0.85 | KDM4E (0.66) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9636808 | 0.83 | KDM4E (0.54) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| Hydrochloric Acid SCHEMBL11188305 | 0.83 | KDM4E (0.55) | KDM4EHPGDHSD17B10ALDH1A1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |