Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3437992 | 0.81 | NPC1 (0.51) | GRM5KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL2737283 | 0.77 | NPC1 (0.61) | GRM5KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL13567899 | 0.77 | NPC1 (0.48) | GRM5KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL9524664 | 0.76 | KEAP1 (0.52) | KMT2AKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL23490153 | 0.74 | NPC1 (0.51) | GRM5KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL6845144 | 0.74 | NPC1 (0.51) | GRM5KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7463707 | 0.74 | CYP19A1 (0.60) | KMT2AALDH1A1MAPTTP53HPGD | |
| SCHEMBL9663826 | 0.74 | HPGD (0.40) | KMT2AKDM4EALDH1A1MAPTGAA | |
| SCHEMBL18713730 | 0.73 | NPC1 (0.50) | GRM5KMT2AKDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1915989 | 0.73 | NPC1 (0.50) | GRM5KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500435-A | BENZIMIDAZOLES AND BENZOTRIAZOLES, TREATMENT OF RETINOID SENSITIVE SKIN DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1996-03-19 | — | — | US | disclosed |
| US-5420147-A | Benzimidazoles, benzotriazoles, controlling metabolism of retinoids, skin cancer | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-05-30 | — | — | US | disclosed |
| EP-0371559-B1 | Use of benzimidazoles in the treatment of epithelial disorders | JANSSEN PHARMACEUTICA NV (BE) | 1994-10-12 | — | — | EP | disclosed |
| US-5342957-A | Suppress the metabolism of retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-08-30 | — | — | US | disclosed |
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-5157046-A | Systemic or topical application of substituted benzimidazole or benzotriazole which suppresses retinoid metabolism | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-10-20 | — | — | US | disclosed |
| EP-0371559-A2 | Use of benzimidazoles in the treatment of epithelial disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |