Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078415 | 0.93 | KDM4E (0.68) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9080171 | 0.92 | KDM4E (0.58) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9078802 | 0.90 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9079800 | 0.89 | KDM4E (0.66) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9078747 | 0.89 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9078046 | 0.87 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL10459451 | 0.86 | KDM4E (0.65) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9080772 | 0.85 | KCNH2 (0.45) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9080323 | 0.84 | KDM4E (0.68) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| SCHEMBL9078550 | 0.82 | TOP2A (0.46) | KDM4EHSD17B10ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |