Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444257 | 0.93 | KCNH2 (0.60) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL8958724 | 0.88 | SMN1; SMN2 (0.63) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| Hydrochloric Acid SCHEMBL9077240 | 0.87 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| Hydrochloric Acid SCHEMBL9077228 | 0.87 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL9077354 | 0.86 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL8958804 | 0.85 | SMN1; SMN2 (0.72) | CYP2D6CYP2C19POLBLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9227219 | 0.85 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL9090842 | 0.84 | KCNH2 (0.54) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL9444451 | 0.84 | KCNH2 (0.60) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL9077025 | 0.83 | KCNH2 (0.50) | KCNH2CYP3A4CYP2D6CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532629-A4 | — | — | 1994-03-09 | — | — | EP | claimed |
| EP-0532629-A1 | 1-PYPERIDINYL ALKANOYLARYLSULFONAMIDE DERIVATIVES. | MERRELL DOW PHARMA (US) | 1993-03-24 | — | — | EP | claimed |
| WO-1991018603-A1 | 1-PYPERIDINYL ALKANOYLARYLSULFONAMIDE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-12-12 | — | — | WO | claimed |
| EP-0532629-B1 | 1-PIPERIDINYL ALKANOYLARYLSULFONAMIDE DERIVATIVES | MERRELL PHARMA INC (US) | 1996-11-06 | — | — | EP | disclosed |
| US-5478846-A | 1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-12-26 | — | — | US | disclosed |
| EP-0532629-A4 | — | — | 1994-03-09 | — | — | EP | disclosed |
| EP-0532629-A1 | 1-PYPERIDINYL ALKANOYLARYLSULFONAMIDE DERIVATIVES. | MERRELL DOW PHARMA (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991018603-A1 | 1-PYPERIDINYL ALKANOYLARYLSULFONAMIDE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-12-12 | — | — | WO | disclosed |