Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | UBE2N | P61088 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499649 | 0.88 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAHTTALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL9502312 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAHTTALDH1A1KMT2A | |
| SCHEMBL9079271 | 0.85 | KCNH2 (0.56) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL8958724 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL9501099 | 0.82 | LMNA (0.68) | SMN1; SMN2LMNAHTTKMT2APOLB | |
| SCHEMBL7302996 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL27258181 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL7302989 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL6202951 | 0.81 | LMNA (0.68) | SMN1; SMN2LMNAHTTALDH1A1KMT2A | |
| SCHEMBL27258188 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAHTTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500433-A | PIPERIDINYL MEDICINAL AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0437790-B1 | Antithrombotic compounds | MERRELL DOW PHARMA (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5292752-A | N-(p-fluorobenzoylmethyl)-4-(p-amidobenzoyl)piperidines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0437790-A2 | Antithrombotic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-07-24 | — | — | EP | disclosed |