Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21642546 | 0.80 | BRD4 (0.43) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL15534813 | 0.78 | KMT2A (0.60) | KMT2AMEN1MAPTELANEALDH1A1 | |
| SCHEMBL9082101 | 0.78 | CHEK1 (0.47) | MAPTELANEALDH1A1SMN1; SMN2MITF | |
| SCHEMBL13405553 | 0.74 | MAPT (0.49) | KMT2AMEN1MAPTELANEALDH1A1 | |
| SCHEMBL2422853 | 0.71 | MAPT (0.53) | KMT2AMEN1MAPTELANEALDH1A1 | |
| SCHEMBL30881347 | 0.70 | ALDH1A1 (0.48) | KMT2AMEN1MAPTELANEALDH1A1 | |
| SCHEMBL20569346 | 0.70 | ALDH1A1 (0.48) | KMT2AMEN1MAPTELANEALDH1A1 | |
| SCHEMBL15908736 | 0.68 | MAPT (0.55) | MAPTELANEALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7806825 | 0.67 | KMT2A (0.54) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL4493009 | 0.67 | SMN1; SMN2 (0.47) | MAPTELANEALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559106-A | Heterocyclic compounds, their use and preparation | NOVO NORDISK A/S (DK) | 1996-09-24 | — | — | US | disclosed |
| EP-0691969-A1 | [1,2,4] TRIAZOLO [4,3-a] QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994021639-A1 | [1,2,4] TRIAZOLO [4,3-a] QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-09-29 | — | — | WO | disclosed |