Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26922790 | 0.86 | TAAR1 (0.56) | HTTPOLBTLR8MCHR1MAPT | |
| SCHEMBL891577 | 0.84 | L3MBTL1 (0.62) | HTTPOLBTLR8MCHR1MAPT | |
| SCHEMBL18893506 | 0.84 | HTT (0.53) | HTTPOLBTLR8MCHR1MAPT | |
| 1,2-Diisopentoxybenzene SCHEMBL2843498 | 0.82 | HTT (0.62) | HTTPOLBTLR8MCHR1MAPT | |
| SCHEMBL10650264 | 0.82 | HTT (0.51) | HTTPOLBTLR8MCHR1MAPT | |
| SCHEMBL14009301 | 0.81 | HTR2C (0.49) | TLR8MAPT | |
| SCHEMBL23966333 | 0.81 | HTT (0.50) | HTTPOLBTLR8MCHR1MAPT | |
| SCHEMBL27533305 | 0.81 | POLB (0.51) | HTTPOLBTLR8MCHR1MAPT | |
| SCHEMBL12408539 | 0.81 | KDM4E (0.52) | MAPTSMN1; SMN2TP53HPGDL3MBTL1 | |
| SCHEMBL2911943 | 0.79 | MAPT (0.52) | TLR8MCHR1MAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |