Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.45 |
| ▸ | TOP1 | P11387 | 7/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079450 | 0.97 | TOP2A (0.46) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9080384 | 0.92 | KDM4E (0.49) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9078492 | 0.88 | KDM4E (0.48) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9078550 | 0.87 | TOP2A (0.46) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL10769256 | 0.85 | TOP2A (0.59) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9078811 | 0.85 | KDM4E (0.49) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9077946 | 0.83 | TOP2A (0.39) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9079778 | 0.82 | ALDH1A1 (0.44) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9078406 | 0.82 | KDM4E (0.54) | TOP2ATOP1TOP2BALDH1A1KDM4E | |
| SCHEMBL9080376 | 0.82 | ALDH1A1 (0.63) | TOP2ATOP2BALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |