Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852730 | 0.89 | MAOB (0.55) | MRGPRX4MAOB | |
| SCHEMBL9080535 | 0.87 | MRGPRX4 (0.60) | MRGPRX4MAOBFFAR1ALOX5LTB4R | |
| SCHEMBL670027 | 0.87 | MAOB (0.68) | MAOBFFAR1LTB4RLTB4R2 | |
| SCHEMBL9270474 | 0.84 | MAOB (0.59) | MRGPRX4MAOBALOX5LTB4RLTB4R2 | |
| SCHEMBL265881 | 0.83 | L3MBTL1 (0.56) | ALOX5 | |
| SCHEMBL14021715 | 0.83 | CYSLTR2 (0.56) | MRGPRX4MAOBFFAR1 | |
| SCHEMBL9186121 | 0.82 | MAOB (0.74) | MRGPRX4MAOB | |
| SCHEMBL13462884 | 0.81 | CYP1A2 (0.65) | MRGPRX4MAOBALOX5TLR4TLR2 | |
| SCHEMBL5116303 | 0.79 | PTPN1 (0.63) | MRGPRX4MAOBFFAR1ALOX5 | |
| SCHEMBL18537208 | 0.78 | L3MBTL1 (0.51) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519022-A | α, α dialkylbenzyl derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-05-21 | — | — | US | disclosed |
| US-5288742-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-22 | — | — | US | disclosed |
| EP-0505122-A1 | Alpha, alpha-dialkylbenzyl derivatives | ZENECA LIMITED (GB) | 1992-09-23 | — | — | EP | disclosed |