Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 10/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079571 | 0.92 | KCNH2 (0.47) | KDM4EPOLBKCNH2CACNA1FMAPK1 | |
| SCHEMBL9080377 | 0.90 | POLB (0.43) | KDM4EPOLBKCNH2CACNA1FMAPK1 | |
| SCHEMBL9080555 | 0.84 | POLB (0.57) | POLBKCNH2CACNA1FMAPK1CACNA1D | |
| SCHEMBL9079454 | 0.84 | KDM4E (0.53) | KDM4EPOLBKCNH2ALDH1A1CHRM2 | |
| SCHEMBL9080499 | 0.83 | POLB (0.41) | POLBKCNH2CACNA1FMAPK1CACNA1D | |
| SCHEMBL9080703 | 0.83 | CACNA1F (0.48) | KDM4EPOLBKCNH2CACNA1FMAPK1 | |
| SCHEMBL9079944 | 0.81 | KDM4E (0.52) | KDM4EPOLBKCNH2ALDH1A1CHRM2 | |
| SCHEMBL9080477 | 0.80 | KDM4E (0.65) | KDM4EPOLBKCNH2MAPK1ALDH1A1 | |
| SCHEMBL9080126 | 0.80 | KDM4E (0.42) | KDM4EPOLBKCNH2CACNA1FMAPK1 | |
| SCHEMBL9080138 | 0.79 | EPHA2 (0.43) | KDM4EPOLBKCNH2CACNA1FMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |