Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | TOP1 | P11387 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9077990 | 0.96 | KDM4E (0.63) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9078399 | 0.92 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9079454 | 0.91 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9080617 | 0.88 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9079944 | 0.88 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9079571 | 0.84 | KCNH2 (0.47) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL8775414 | 0.84 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL9077692 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9080092 | 0.84 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9667565 | 0.82 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |