⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498079 | 0.86 | OR51E2 (0.31) | — | |
| SCHEMBL23651599 | 0.78 | — | — | |
| SCHEMBL24447537 | 0.70 | PARP10 (0.33) | — | |
| SCHEMBL24435657 | 0.68 | — | — | |
| SCHEMBL3833170 | 0.67 | CRBN (0.40) | — | |
| SCHEMBL8125513 | 0.67 | — | — | |
| SCHEMBL2504001 | 0.67 | — | — | |
| SCHEMBL16423308 | 0.67 | ALDH1A1 (0.36) | — | |
| SCHEMBL24384896 | 0.65 | HTR2C (0.31) | — | |
| SCHEMBL20809203 | 0.64 | PDPK1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024146906-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2024-07-11 | — | — | WO | disclosed |
| CN-103304565-B | The medical usage of Vindoline derivative | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-11 | — | — | CN | disclosed |
| CN-102822174-B | Material for organic electroluminescent device | MERCK PATENT GMBH (DE) | 2016-05-04 | — | — | CN | disclosed |
| CN-103304565-A | Vindoline derivative medical application | SHANGHAI INST MATERIA MEDICA | 2013-09-18 | — | — | CN | disclosed |
| EP-1995292-A1 | Organic electroluminescent device | FUJIFILM Corporation (JP) | 2008-11-26 | — | — | EP | disclosed |
| EP-1857452-A1 | CONDENSATION COMPOUND BETWEEN FLUORINATED CYCLOPENTANE RING AND AROMATIC RING, AND PROCESS FOR PRODUCING THE SAME | OSAKA UNIVERSITY (JP) | 2007-11-21 | — | — | EP | disclosed |
| EP-0444854-B1 | 6-Substituted hexahydrobenz[cd]indoles | LILLY CO ELI (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5470853-A | Useful in modifying the serotonin function in the body | ELI LILLY AND COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| US-5302612-A | Modify the serotonin function in the body; anxiolytic agents; antidepressants; hypotensive agents | ELI LILLY AND COMPANY (US) | 1994-04-12 | — | — | US | disclosed |
| EP-0444854-A2 | 6-Substituted hexahydrobenz[cd]indoles | ELI LILLY AND COMPANY (US) | 1991-09-04 | — | — | EP | disclosed |
| US-4192874-A | Substituted 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-03-11 | — | — | US | disclosed |
| US-4186199-A | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |
| US-4186199-A | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |