Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 14/20 | 0.50 |
| ▸ | LPAR5 | Q9H1C0 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9080294 | 0.95 | LPAR1 (0.52) | LPAR1LPAR5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9081278 | 0.89 | LPAR1 (0.48) | LPAR1LPAR5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9080794 | 0.87 | LPAR1 (0.47) | LPAR1LPAR5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29842627 | 0.87 | LPAR1 (0.47) | LPAR1LPAR5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9081536 | 0.86 | LPAR1 (0.47) | LPAR1LPAR5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9082575 | 0.85 | LPAR1 (0.56) | LPAR1LPAR5LPAR3 | |
| SCHEMBL9079713 | 0.84 | STAT3 (0.51) | LPAR1LPAR5LPAR3 | |
| SCHEMBL9081773 | 0.84 | LPAR1 (0.53) | LPAR1LPAR5TSHRLPAR3TDP1 | |
| SCHEMBL9081561 | 0.83 | LPAR1 (0.44) | LPAR1LPAR5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9081632 | 0.83 | LPAR1 (0.53) | LPAR1LPAR5KDM4ETSHRLPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |