Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ATM | Q13315 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | CASP7 | P55210 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10400378 | 0.94 | KDM4E (0.59) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL30967314 | 0.92 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL3767347 | 0.92 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL293611 | 0.92 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL9697492 | 0.92 | HSD17B10 (0.62) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL8013837 | 0.91 | POLB (0.58) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL29586986 | 0.91 | POLB (0.58) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL126043 | 0.90 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL29492994 | 0.90 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL6339253 | 0.89 | POLB (0.61) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |