Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9082563 | 0.92 | LPAR1 (0.49) | TSHRLPAR1 | |
| SCHEMBL9082619 | 0.86 | LPAR1 (0.51) | LPAR1 | |
| SCHEMBL9080669 | 0.84 | LPAR1 (0.48) | ALDH1A1KDM4ELPAR1ALOX5 | |
| SCHEMBL9081531 | 0.82 | TSHR (0.64) | TSHRLMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL9081241 | 0.81 | TSHR (0.56) | TSHRLPAR1TDP1ALOX5 | |
| SCHEMBL9081269 | 0.81 | LPAR1 (0.54) | LPAR1 | |
| SCHEMBL9081215 | 0.81 | TSHR (0.55) | TSHRKDM4ELPAR1TDP1 | |
| SCHEMBL9080531 | 0.81 | TSHR (0.55) | TSHRKDM4ELPAR1TDP1 | |
| SCHEMBL9080371 | 0.81 | TSHR (0.55) | TSHRKDM4ELPAR1TDP1 | |
| SCHEMBL9081721 | 0.81 | TSHR (0.55) | TSHRKDM4ELPAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |