Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.48 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.46 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9082563 | 0.87 | LPAR1 (0.49) | LPAR1LPAR5PPARG | |
| SCHEMBL9080720 | 0.84 | TSHR (0.50) | LPAR1ALOX5KDM4EALDH1A1 | |
| SCHEMBL9080655 | 0.82 | PTGES (0.60) | LPAR1LPAR5PTGESP2RX3P2RX2 | |
| SCHEMBL9080794 | 0.82 | LPAR1 (0.47) | LPAR1LPAR5PTGESFFAR1P2RX3 | |
| SCHEMBL29842627 | 0.82 | LPAR1 (0.47) | LPAR1LPAR5PTGESFFAR1P2RX3 | |
| SCHEMBL9082619 | 0.82 | LPAR1 (0.51) | LPAR1LPAR5PPARG | |
| SCHEMBL9082788 | 0.81 | LPAR1 (0.53) | LPAR1LPAR5PTGESP2RX3P2RX2 | |
| SCHEMBL9080350 | 0.81 | LPAR1 (0.54) | LPAR1LPAR5PTGESP2RX3P2RX2 | |
| SCHEMBL9080108 | 0.81 | LPAR1 (0.54) | LPAR1LPAR5PTGESFFAR1 | |
| SCHEMBL9081269 | 0.78 | LPAR1 (0.54) | LPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |